Search results for "Epinephrine uptake"

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Methamphetamine abuse and meth mouth in Europe

2014

With easy chemical synthesis from its precursor, methamphetamine (MA) is now widespread in many countries. The abuse of methamphetamine is associated with several negative effects on health, because MA is a neurotoxin and a dangerous central nervous system stimulant. It changes levels of neurotransmitters in the brain, releasing dopamine and inhibiting nor epinephrine uptake which increases sympathetic nervous system activity and can lead to cardiac arrhythmia, hypertension and tachypnea. The consequences of MA abuse are clearly manifested in oral diseases (like “meth mouth”) which is characterised by extensive caries, teeth grinding with ensuing dental wear and trismus. The present review …

medicine.medical_specialtySympathetic nervous systemOral healthAmphetamine-Related DisordersOdontologíaReviewTrismusDrug abuseTachypneaMethamphetamineDevelopmental psychology“Meth mouth”DopaminemedicineHumansmedia_common.cataloged_instanceEuropean unionPsychiatryGeneral Dentistrymedia_commonEpinephrine uptakebusiness.industryMethamphetamineMedically compromised patients in Dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCiencias de la saludMeth mouthEuropemedicine.anatomical_structureOtorhinolaryngologyTooth DiseasesUNESCO::CIENCIAS MÉDICASDrug abuse; Methamphetamine; Oral health; “Meth mouth”;Surgerymedicine.symptomMouth Diseasesbusinessmedicine.drugMedicina Oral Patología Oral y Cirugia Bucal
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Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans

2004

BACKGROUND: St John's wort (Hypericum perforatum) is a popular over-the-counter antidepressant. Its antidepressive effect has been attributed in part to inhibition of monoamine transporters and monoamine oxidase, on the basis of in vitro studies. METHODS: In a double-blind, randomized, placebo-controlled, crossover study, 16 healthy subjects (11 men and 5 women; mean age, 31 +/- 5 years) ingested either St John's wort (300 mg three times daily) or placebo for 7 days. Imipramine treatment (50 mg three times daily) in 7 subjects served as a positive control. After treatment, physiologic and biochemical tests included cardiovascular reflex testing, graded head-up tilt testing, and plasma catec…

AdultMaleNitroprussideImipraminemedicine.medical_specialtyPosturePharmacologyAutonomic Nervous SystemPlaceboMethoxyhydroxyphenylglycolNorepinephrine uptakeCardiovascular Physiological PhenomenaNorepinephrineCatecholaminesDouble-Blind MethodInternal medicineHeart rateSupine PositionmedicineHumansNitric Oxide DonorsPharmacology (medical)PeryleneAnthracenesPharmacologyCross-Over StudiesAdrenergic Uptake Inhibitorsbusiness.industryHemodynamicsHypericum perforatumEndocrinologyBlood pressureMonoamine neurotransmitterCatecholamine34-Dihydroxyphenylacetic AcidAntidepressantFemalebusinessHypericummedicine.drugClinical Pharmacology & Therapeutics
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